Wafer connectors are very similar to headers. The main difference is that these connectors are more suitable as actual connectors as opposed to a place to attach some wires. Here are the particular differences and similarities:
These connectors are polarized which means you can’t plug the mating connector in the wrong way.
Male connectors are attached to your PCB, while the female are attached to a wire cable.
Female connectors are crimped on, so no soldering is required (soldering is optional though).
The pin spacing is the same as headers, so they are compatible with each other.
Housing are generally made of only plastic parts (some have metal parts), which are assembled with wire and terminal wafer.

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